|
T9622 |
MF-766
|
|
Prostaglandin Receptor
|
|
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1.8 nM in the presence of 10% HS) in the functional assay. It... |
|
T5310 |
TR-14035
|
MDK-1191 |
Integrin
|
|
TR-14035 (MDK-1191) is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM). |
|
T7644 |
DPN
|
Diarylpropionitrile |
Apoptosis
,
Estrogen Receptor/ERR
,
Estrogen/progestogen Receptor
,
Autophagy
|
|
DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) . |
|
T6593 |
ML324
|
|
Histone Demethylase
,
Others
,
HSV
|
|
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). |
|
T6561 |
Laquinimod
|
LAQ,ABR-215062 |
Apoptosis
,
Others
,
NF-κB
|
|
Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oral therapy. |
|
T1090 |
Perphenazine
|
Perphenazin,Etaperazine,Trilafon |
CaMK
,
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Perphenazine (Trilafon) is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. |
|
T4583 |
PFI-2 hydrochloride
|
(R)-PFI-2 hydrochloride,PFI-2 HCl |
Histone Methyltransferase
|
|
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. |
|
T9999 |
Sirtuin modulator 2
|
N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide |
Others
,
Sirtuin
|
|
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities. |
|
T0487 |
Metoprolol tartrate
|
CGP 2175E |
Adrenergic Receptor
|
|
Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor. |
|
T1987 |
PFI-2
|
PFI2,PFI 2,(R)-PFI-2 |
Histone Methyltransferase
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. |
|
T12850 |
Dilmapimod
|
SB-681323,GW 681323 |
p38 MAPK
,
Autophagy
|
|
Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease. |
|
T17289 |
ZED-1227
|
ZED-101,TAK-227 |
Others
,
Glutaminase
|
|
ZED-1227 (TAK-227) is an orally active, selective and potent transglutaminase 2 (TG2) inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Disease. |
|
T78525 |
IRG1-IN-1
|
|
Others
|
|
IRG1-IN-1 is an itaconic acid derivative with the ability to inhibit the activity of Immune Response Gene 1 (IRG1) and is suitable for use in the field of cancer, inflammation and autoimmune disease research. |
|
T11179 |
Elubrixin
|
SB-656933 |
IL Receptor
,
CXCR
|
|
Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammat... |
|
T38715 |
MSDC-0602K
|
MSDC-0602K,Azemiglitazone potassium |
PPAR
|
|
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (... |
|
T72031 |
BI 1015550
|
|
PDE
|
|
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo... |
|
T24997 |
ABT-510 acetate
|
ABT 510 acetate |
Apoptosis
|
|
ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth i... |
|
T73695 |
Canakinumab
|
ACZ 885,Ilaris |
IL Receptor
|
|
Canakinumab (ACZ885) is a recombinant human IL-1β-targeting monoclonal antibody.Canakinumab has been shown to inhibit human and chorioallantoic monkey IL-1β, with IC50 values of 43.6 and 40.8 pM, respectively.Canakinumab... |
|
T111959 |
IFB-088 acetate
|
|
|
|
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... |
|
T26917 |
BTT-3033
|
BTT3033,BTT 3033 |
Apoptosis
,
Integrin
|
|
BTT-3033 is an orally active and potent α2β1 (EC50: 130 nM) inhibitor with an EC50 value of 130 nM. BTT-3033 has an affinity for the α2I domain and inhibits platelet binding to collagen I and cell proliferation.BTT-3033 ... |
|
T2171 |
SEW2871
|
SEW2871 |
S1P Receptor
,
LPL Receptor
|
|
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... |
|
T60522 |
Letosteine
|
Viscotiol |
Others
|
|
Letosteine (Viscotiol) is an orally active, effective, and safe expectorant that can be used in the study of acute or chronic respiratory diseases, for example, bronchopulmonary disease. Letosteine dissolves bronchial mu... |
|
T10865 |
Cot inhibitor-1
|
|
TNF
,
MAPK
|
|
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM). Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a... |
|
T13604 |
CDDO-dhTFEA
|
|
Others
,
NF-κB
,
Nrf2
|
|
CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expressi... |
|
T21967 |
MEG hemisulfate
|
Mercaptoethylguanidine hemisulfate |
NOS
|
|
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS i... |
|
TP2309 |
NEUROTENSIN TFA (39379-15-2 free base)
|
Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH TFA（55508-42-4 free base),NEUROTENSIN TFA |
Others
|
|
Neurotensin TFA (39379-15-2 free base) is an endogenous 13 amino acid neuropeptide with profound opioid-independent analgesic effects. It behaves as a neurotransmitter in the brain, as a hormone in the gut, and also as a... |
|
T28878 |
Sul-121 HCl
|
Sul-121 Hydrochloride |
|
|
Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidati... |
|
T63818 |
Omesdafexor
|
|
|
|
Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation. |
|
T61804 |
GSK-3β inhibitor 6
|
|
|
|
GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying vario... |
|
T60457 |
COX-2-IN-11
|
|
|
|
COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1]. |
|
T32156 |
Indimilast
|
|
|
|
Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cel... |
|
T62029 |
ML261
|
|
|
|
ML261 is a inhibitor of hepatic lipid droplets formation with an IC 50 of 69.7 nM. ML261 has research value in non-alcoholic fatty liver disease (NAFLD) and inflammation. |
|
T73262 |
C5aR-IN-3
|
|
|
|
C5aR-IN-3, a potent C5aR inhibitor, holds potential for inflammation disease research due to its ability to counteract increased C5a levels, which are linked to autoimmune and inflammatory disorders. |
|
T73335 |
P2X7-IN-2
|
|
|
|
P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and car... |
|
T41121 |
Elubrixin tosylate
|
SB-656933 tosylate,Elubrixin tosylate |
|
|
Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b ... |
|
T76056 |
Glepaglutide
|
|
|
|
Glepaglutide (ZP1848), a long-acting glucagon-like peptide-2 (GLP-2) analogue, functions as a potent agonist of the GLP-2 receptor (GLP-2R), effectively reducing fecal output and enhancing intestinal absorption, while al... |
|
T76947 |
Ziltivekimab
|
|
|
|
Ziltivekimab (COR-001), a human anti-IL-6 monoclonal antibody, efficiently lowers serum CRP levels and exhibits anti-inflammatory properties. It is potentially useful in researching chronic systemic inflammation and card... |
|
T78552 |
PB118
|
|
|
|
PB118 has the capacity to effectively clear Aβ deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl α-tubulin levels, modulate various inflammation-associated cytokines an... |
|
T76057 |
Glepaglutide acetate
|
|
|
|
Glepaglutide (ZP1848) acetate is a long-acting glucagon-like peptide-2 (GLP-2) analogue and a potent GLP-2 receptor (GLP-2R) agonist. It significantly reduces fecal output and enhances intestinal absorption while also mi... |
|
T75254 |
P2X7-IN-2 TFA
|
|
|
|
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammati... |
|
T61130 |
SSTR4 agonist 3
|
|
|
|
SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease... |
|
T62937 |
MAGLi 432
|
|
|
|
MAGLi 432 is a potent, highly selective, non-covalent, reversible (MAGL) inhibitor that binds with high affinity to the MAGL active site, with IC50 values of 4.2 nM (human enzyme) and 3.1 nM (mouse enzyme), MAGLi 432 can... |
|
T80771 |
WRR139
|
|
|
|
WRR139, a peptide vinyl sulfone, plays a role in disease processes including inflammation and cancer, and acts as an inhibitor of cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1. Moreover, WRR139 amplifies the cytotoxic ... |
|
T26447 |
A 78773
|
A78773,A-78773 |
|
|
A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tis... |
|
T73470 |
PF-184
|
|
|
|
PF-184 is a potent, selective inhibitor of IKK-2 with an IC50 value of 37 nM, demonstrating significant selectivity over rhIKK-1, IKKi, and over 30 other tyrosine and serine/threonine kinases. It is utilized in inflammat... |
|
T80599 |
Dectrekumab
|
QAX576 |
|
|
Dectrekumab (QAX576), a humanized monoclonal antibody targeting IL-13, significantly reduces intraepithelial esophageal eosinophil counts and normalizes dysregulated esophageal disease-related transcripts in Eosinophilic... |
|
T72889 |
FXR agonist 4
|
|
|
|
FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ... |
|
T38305 |
Tetranor-PGAM
|
|
|
|
Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 i... |
|
T82663 |
CU06-1004
|
Sac-1004 |
|
|
CU06-1004 (Sac-1004) is an orally active compound that acts as an endothelial dysfunction blocker. It mitigates endothelial dysfunction by inhibiting hyperpermeability and inflammation. The compound demonstrates efficacy... |
|
T27809 |
LEI-101
|
|
|
|
LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC 50 of 8 for hCB2, and a pK i of less than 4 for hERG. LEI-101 is ~100-fold more potent in binding to CB2 receptors than... |
